Immunolocalization of X-arrestin in human cone photoreceptors
نویسندگان
چکیده
منابع مشابه
Mouse cone arrestin expression pattern: light induced translocation in cone photoreceptors.
PURPOSE Arrestins are a superfamily of regulatory proteins that down-regulate activated and phosphorylated G-protein coupled receptors (GPCRs). Cone arrestin (CAR) is expressed in cone photoreceptors and pinealocytes and may contribute to the shutoff mechanisms associtated with high acuity color vision. To initiate a study of CAR's function in cone phototransduction, the mouse CAR (mCAR) transc...
متن کاملInteraction of arrestin with enolase1 in photoreceptors.
PURPOSE Arrestin is in disequilibrium in photoreceptors, translocating between inner and outer segments in response to light. The purpose of this project was to identify the cellular component with which arrestin associates in the dark-adapted retina. METHODS Retinas were cross-linked with 2.5 mM dithiobis(succinimidylpropionate) (DSP), and arrestin-containing complexes purified by anion-exch...
متن کاملIntrinsic signals from human cone photoreceptors.
PURPOSE To develop noninvasive means to relate structure to function in human eyes, the authors investigated intrinsic retinal signals at high resolution using an adaptive optics scanning laser ophthalmoscope (AOSLO). METHODS The AOSLO was used in dual-wavelength mode to stimulate the retina with 658 nm visible light and simultaneously to image the retina with 840 nm infrared light. Modulatio...
متن کاملStructure of cone photoreceptors.
Although outnumbered more than 20:1 by rod photoreceptors, cone cells in the human retina mediate daylight vision and are critical for visual acuity and color discrimination. A variety of human diseases are characterized by a progressive loss of cone photoreceptors but the low abundance of cones and the absence of a macula in non-primate mammalian retinas have made it difficult to investigate c...
متن کاملImages of cone photoreceptors in the living human eye
Though the photoreceptor mosaic has been imaged through the intact optics of the eyes of several species, it has not been clear whether individual photoreceptors can be resolved in the living human eye. We have constructed a high-resolution fundus camera and have resolved cones with a spacing as small as 3.5 microns in single images of the fundus. The high contrast of these images implies that ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1996
ISSN: 0014-5793
DOI: 10.1016/0014-5793(96)00163-9